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Hot and cold plate pain meter

Hot and cold plate pain meter

At present, the screening test methods (physical methods) for acute pain analgesics are basically hot plate test, tail flick test or animal plantar tenderness irradiation test, but these are the normal stimulation response thresholds of animals, which belong to a kind of physiological pain. Physiological pain is essentially different from pathological pain. Physiological pain is an alarm system for self-protection for survival, while pathological pain is a disease that hinders survival. Due to the different manifestations and mechanisms of the two types of pain, their experimental methods for analgesic drugs are also different. For example, some analgesic drugs have better analgesic effects on physiological and pathological pain. However, some drugs only have an effect on physiological pain, so different experimental methods and instruments can be used to screen out drugs with different points of action. The hot and cold plate pain measuring instrument is an instrument that can complete the physiological pain experiment and the pathological pain experiment on the same instrument.

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plantar tenderizer

plantar tenderizer

The plantar touch allodynia test is currently an internationally and domestically recognized experimental method for screening analgesic drugs. Objective factors (such as: holding, tying, pulling, twisting, etc.) make the pain threshold of the animal truly manifest. The plantar touch sensitivity test is developed on the basis of the plantar heat sting test, which overcomes a lot of drawbacks in the plantar heat sting test.

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plantar sting system

plantar sting system

The plantar stinging system, also known as the mechanical stinging instrument, is developed with high-precision and high-stability sensing elements, and one measurement is accurate to the tactile threshold of 0.1g. The instrument acts on various body parts of animals by means of mechanical needle stimulation. It is a commonly used instrument in the screening and testing of analgesic drugs. It is also used to determine the mechanism of distinguishing central nerve and peripheral nerve analgesia. It has a relatively wide range of uses. . Real-time changes in sting intensity can be measured, improving the accuracy of pain thresholds.

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Smart Hot Plate Meter

Smart Hot Plate Meter

The instrument is easy to use, has clear indicators, minimal tissue damage, can be used repeatedly by animals, and has a longer pain response latency, which is convenient for observing and measuring small differences between drugs, and comparing the strength, speed and duration of drug analgesia. At the same time, the test data can be exported, and the test experiments on mice, rats and guinea pigs can be conveniently completed. It is an ideal instrument for teaching and scientific research. It is one of the more advanced hot plate instruments at home and abroad.

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Toe volume meter

Toe volume meter

Toe volume measuring instrument is an instrument used for screening and identification of antipyretic and anti-inflammatory drugs. It is a method to evaluate the potency of drugs by measuring the swelling process of rat toes after inflammation and swelling, and to understand the action time and efficacy of drugs. regular instrument. The instrument has the advantages of accurate measurement, accurate timing, accurate printing accuracy and convenience in operation. Compared with similar foreign products, the instrument has improved a grade in terms of style, structure and accuracy, but the use of medium (liquid) Requirements and technical requirements for operation are far lower than similar foreign products.

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hot stinger

hot stinger

ZS-RCT-200 heat stinger is another successful product independently developed after summarizing the advantages and disadvantages of similar products at home and abroad. Have independent intellectual property rights. It adopts new methods and new technologies such as fast approach, slow stab, automatic recording, data storage and printing, PC online, etc., which makes complex and difficult experiments (such as: inverted feet, inaccurate positioning) convenient. , simple and fast. The stimulation site is precise and consistent, which ensures the real effect of the experiment. The mouse box part of the instrument is an assembly structure, which is easy to disassemble, reasonable in structure, easy to clean, and elegant at the same time.

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Thermal runaway tester

Thermal runaway tester

The thermal escape tester can adjust the temperature arbitrarily between 2°C and 66°C, and can also set the temperature range, from low to high or from high to low. As a result, researchers can use it for pain sensitivity tests, to study the cold sensitivity of receptors, or for "dynamic" experiments under temperature changes within a certain temperature range. The real-time temperature is displayed on the LCD screen, the minimum change range is 0.1°C, and the response time is 0.1s.

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Rat tail light pain meter

Rat tail light pain meter

The light tail flicking method is also called the photothermal tail flicking method or the radiant thermal tail flicking method. When the animal produces an effective tail flick to escape, this method to judge the level and change of the animal's pain threshold is called the light tail flick method.

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Channel type rat foot support force measuring instrument

Channel type rat foot support force measuring instrument

Measuring the difference in the support force between the hind paws of rats and mice is currently an advanced method for screening analgesic and anti-inflammatory drugs. Animals will have the strength to support their body weight between the inflammatory and painful feet and the normal feet without restraint. Difference, the greater the difference, the more painful the inflammatory foot, the use of drugs with analgesic effect can reduce the difference, so as to identify the efficacy and role of anti-inflammatory and analgesic drugs.

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Electronic Pain Meter

Electronic Pain Meter

The electronic tenderness instrument is a replacement product of the XZC-A type (balance type) tenderness instrument. It has the functions of accurate pressure, convenient operation, data printing, computer connection, etc. It is one of the most practical instruments for scientific research and teaching, and has been well received by experts and professors in practical use.

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Small animal thrombus generator

Small animal thrombus generator

The instrument uses a physical method (direct current stimulation) to damage the endothelial cells of the carotid artery, thereby activating coagulation factors, starting the coagulation mechanism, causing platelets and fibrin to aggregate, and forming a mixed thrombus, which is similar to the beginning of the human body. Thrombosis, the pathological mechanism of thrombus formation by this method is very similar to that of human beings, and has more practical significance than chemical method (ferric chloride method), hematoporphyrin method, isolated circulation method, and cardiopulmonary bypass silk thread method. Therefore, electrical stimulation The tethering method has been recognized by the world.

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Drinking water electric shock experiment system

Drinking water electric shock experiment system

The ZS-D3000 drinking water electric shock experimental system is a classic animal drinking water electric shock conflict anxiety research experiment. It can detect the efficacy of anti-anxiety drugs and reduce animal resistance behavior through punishment. A large number (up to 64 simultaneous) measurement positions can be detected. The software controls the drinking/shock ratio, shock frequency length, measurement mode, interval recording and overall duration. The number of electric shocks for drinking water in a unit time interval can be automatically transferred to an Excel worksheet.

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