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Morris water maze video analysis system


Morris water maze (MWM) experiment is an experiment in which experimental animals (rats, mice) are forced to swim and learn to find platforms hidden in water. It is mainly used to test the sense of spatial position and direction of experimental animals. (spatial orientation) learning and memory ability. It is widely used in learning and memory, Alzheimer's disease, hippocampal/external hippocampal research, intelligence and aging, new drug development/screening/evaluation, pharmacology, toxicology, preventive medicine, neurobiology, animal psychology and behavioral biology, etc. The fields of scientific research and computer-assisted teaching in the discipline have been widely recognized in the world, and it is a classic experiment for medical schools to carry out behavioral research, especially learning and memory research. One of the main accessories of Morris water maze is the pool. The quality and function of the pool are an indispensable part of the experiment. In the experiment, the temperature of the water temperature is the key to the experiment. has reached the advanced level.

Pre-consultation
Description Parameters Resources

Morris water maze (MWM) experiment is an experiment in which experimental animals (rats, mice) are forced to swim and learn to find platforms hidden in water. It is mainly used to test the sense of spatial position and direction of experimental animals. (spatial orientation) learning and memory ability. It is widely used in learning and memory, Alzheimer's disease, hippocampal/external hippocampal research, intelligence and aging, new drug development/screening/evaluation, pharmacology, toxicology, preventive medicine, neurobiology, animal psychology and behavioral biology, etc. The fields of scientific research and computer-assisted teaching in the discipline have been widely recognized in the world, and it is a classic experiment for medical schools to carry out behavioral research, especially learning and memory research. One of the main accessories of Morris water maze is the pool. The quality and function of the pool are an indispensable part of the experiment. In the experiment the temperature of the water temperature is the key to the experiment. has reached the advanced level.

1. Hardware parameters:

1. Pool material: 304 GB stainless steel

2. Heating power: 3000 watts

3. Temperature accuracy: 0.1℃

4. Specification of rat pool: diameter 150cm, height 60cm

5. Specification of mouse pool: diameter 120cm, height 40cm

6. Rat platform specifications: diameter 12cm, height between 20 ~ 35cm

7. Specifications of mouse platform: 8cm in diameter and 20-35cm in height

8. The pool has wheels, which can be moved at will

9. Temperature control range: room temperature - 80℃

2. Software parameters:

1. One-click drawing area

The labmaze center fixed-point drawing method is convenient to draw the labyrinth area required for the experiment. After the experiment, it is found that a certain area is not drawn, and this area can be temporarily added without re-analyzing the video. The software can directly obtain the indicators of this area.

2. Intelligent AI algorithm

The software automatically recognizes the volume and shape of animals by learning and extracts them from complex backgrounds. It has strong anti-interference ability and filtering ability. Even if there are many ripples that interfere with the picture, it can accurately track animals.

Tracking method: The tip of the nose, the center, and the root of the tail track three points and analyze the data corresponding to the three points at the same time, etc.
3. Diversified experimental process design

The software is openly edited for conditions such as time, area, speed, hardware, steps, events, etc., which is convenient for editing the experimental process mentioned in the literature.

4. Human-computer interaction verification

The software automatically saves the experimental video, and the experimental video and analysis indicators can be played back simultaneously with the same window, verifying the unity of software analysis and manual calculation, and ensuring the authenticity of the analysis results.

5. Rich statistical indicators

The software can analyze more than 200 indicators such as the number of visits, residence time, percentage, moving distance, speed, rotation between regions, trajectory diagrams, time series diagrams, heat map, and event relationships in each area;

6. GLP management

The software has the function of rights management, the administrator assigns the experimental user account and manages the user rights; reviews the operation of the experimenter

7. The software is allowed to be installed on multiple computers, the software is allowed to work on laptop computers, supports online and offline video analysis, and facilitates statistics of data indicators;
3. Data indicators:

Total distance (total activity), total time, latency, average speed, activity distance in the first quadrant, activity time in the first quadrant, activity distance in the second quadrant, activity time in the second quadrant, activity distance in the third quadrant, activity in the third quadrant Time, activity distance in the fourth quadrant, activity time in the fourth quadrant, center activity distance, center activity time, surrounding activity distance, surrounding activity time, activity distance around the platform I, activity time around the platform I, activity distance around the platform II , Activity time in the area around the platform II, activity distance in the area around the platform III, activity time in the area around the platform III, activity distance in the area around the platform IV, activity time in the area around the platform IV, number of times of crossing the platform, etc.

Some published articles

1.A Novel, Multi-Target Natural Drug Candidate,Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

2.A polysaccharide extracted from Astragalus membranaceus residue improves cognitive dysfunction by altering gut microbiota in diabetic mice

3.Bisindole compound 4ae ameliorated cognitive impairment in rats with vascular dementia by anti-inflammation effect via microglia cells

4.Effect of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley rats

5. Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21

For more literature, please consult: 400-016-4066

This parameter is the basic parameter of the equipment, please contact our company for specific parameters

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